Selenium Cytotoxicity in Cancer
نویسندگان
چکیده
منابع مشابه
Selenium cytotoxicity in cancer.
Selenium is an essential trace element with growth-modulating properties. Decades of research clearly demonstrate that selenium compounds inhibit the growth of malignant cells in diverse experimental model systems. However, the growth-modulating and cytotoxic mechanisms are diverse and far from clear. Lately, a remarkable tumour selective cytotoxicity of selenium compounds has been shown, indic...
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متن کاملSelenium compounds are substrates for glutaredoxins: a novel pathway for selenium metabolism and a potential mechanism for selenium-mediated cytotoxicity.
The Grx (glutaredoxin) proteins are oxidoreductases with a central function in maintaining the redox balance within the cell. In the present study, we have explored the reactions between selenium compounds and the glutaredoxin system. Selenite, GS-Se-SG (selenodiglutathione) and selenocystine were all shown to be substrates of human Grx1, implying a novel role for the glutaredoxins in selenium ...
متن کاملSelenium and cancer prevention.
protection selenium provides against certain cancers that I have been taking daily selenium yeast supple ments (100-400 jxg)for 4 years, I am perplexed by the selection of cancers to be studied in related doubleblind clinical trials, namely those of the liver, skin and esophagus. In 1986, I published details of in excess of 13,000 correlations between the distributions of 219 environ mental var...
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BACKGROUND This review is the third update of the Cochrane review "Selenium for preventing cancer". Selenium is a naturally occurring element with both nutritional and toxicological properties. Higher selenium exposure and selenium supplements have been suggested to protect against several types of cancer. OBJECTIVES To gather and present evidence needed to address two research questions:1. W...
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ژورنال
عنوان ژورنال: Basic & Clinical Pharmacology & Toxicology
سال: 2014
ISSN: 1742-7835
DOI: 10.1111/bcpt.12207